Hos den grupp som behandlades med alfa-1-mikroglobulin (A1M), med professor Bo Åkerström vid Lunds universitet står bakom studierna.
α1-microglobulin (A1M) is a small protein present in vertebrates including humans. It has several physiologically relevant properties, including binding of heme and radicals as well as enzymatic reduction, that are used in the protection of cells and tissue. Research has revealed that A1M can ameliorate heme and ROS-induced injuries in cell cultures, organs, explants and animal models.
Mark. Contribution to journal Article; Expression, Purification and Initial Characterization of Functional α 1-Microglobulin (A1M) in Nicotiana benthamiana. Carlsson, Magnus … Bo Åkerström's 186 research works with 5,544 citations and 7,942 reads, including: biomolecules-11-00263-ag.png Ten years ago Bo Åkerström and his research group demonstrated that A1M has the ability to bind the free radicals and the toxic heme molecules and convert them into harmless substances. Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its physiological role remained unknown for a long time. A series of recent publications have demonstrated that A1M is a vital part of tissue hou … The authors Magnus Gram and Bo Åkerström are founders and share-holders of A1M Pharma. This does not alter the authors’ adherence to the policies of IJMS regarding sharing data and materials.
Lyssna på berättelsen om forskarkarriären där det lilla proteinet A1M Stefan Hansson, som tillsammans med professor Bo Åkerström leder Behandlingen är ett protein, Alpha-1-mikroglobulin, även kallat A1M. hoppade på nyemissionen i A1M Pharma i början av sommaren var att grundaren heter Bo Åkerström och är sångare i kultbandet Torsson och från A1M Pharma träffar ni VD Tomas Eriksson och forskningschefen Bo Åkerström. Rapidusbaren äger rum torsdagen den 23 maj kl. Stefan Hansson har tillsammans med professor Bo Åkerström lyckats identifiera ett protein, alfa-1-microglobulin (A1M), som kan vara grunden o A1M Pharma utvecklar biologisk läkemedelskandidat som bygger på kroppseget När Bo Åkerström, en av bolagets grundare, 1974 började. Historien om läkemedelsbolaget A1M Pharma startade redan 1974 när Bo Åkerström, idag professor vid Lunds universitet, började studera det kroppsegna Forskningsbolaget A1M Pharma har gjort ett omtag på både finansiell Professor Bo Åkerström har forskat på det kroppsegna proteinet A1M The aims of this project are to 1) investigate protective mechanisms of A1M, 2) develop a large-scale purification process of A1M for in vivo studies, and 3) Koordinerande organisation: Lunds universitet; Projektledare: Bo Åkerström. fungerar ihop är något professor Bo Åkerström ibland funderar över. att studera proteinet A1M som finns hos alla däggdjur och är en viktig Fredrik Olsson är genom bolaget Private placement sprl största ägare i A1M i Lund grundat av forskarna Stefan Hansson, Bo Åkerström och Magnus Gram A1M Pharma arbetar nu för fullt med ett test som på ett tidigt stadium kan Då inledde han och Bo Åkerström ett samarbete med Stefan Bakom förslaget står större aktieägare i A1M Pharma. De tidigare styrelseledamöterna Bo Åkerström och Stefan Hansson har avböjt omval men fortsätter sitt När det gäller behandling för sjukdomen har forskarna i samarbete med professor Bo Åkerström studerat proteinet alfa-1-mikroglobulin, A1M, Guard Therapeutics International AB hette tidigare A1M Pharma AB. Ägare: Private Placement SPRL 26,0 %, Bo Åkerström 17,1 %, Stefan Hansson 12,3 % Hos den grupp som behandlades med alfa-1-mikroglobulin (A1M), med professor Bo Åkerström vid Lunds universitet står bakom studierna.
oxidative stress, antioxidation, alpha-1-microglobulin, A1M, hemoglobin, hemolysis, Helena Karlsson, Wahed Zedan, Magnus Gram, Bo Åkerström, Sven-Erik
A1M Pharma meddelar att bolagets medgrundare Bo Åkerströms forskargrupp har tilldelats ett anslag om 1,2 MSEK från Vetenskapsrådet. I dagens Söndagsintervju har BioStock intervjuat både professor Bo Åkerström, grundare av A1M Pharma och senior ansvarig för preklinisk På punkt efter punkt har Bo Åkerström och hans forskningsteam visat att molekylen, nu döpt till A1M, är en av de allra viktigaste för kroppens Och inte bara det, A1M kan även reparera oxiderade blodfetter, säger Bo Åkerström som är professor vid Medicinska fakulteten i Lund.
microglobulin/A1M in human rhegmatogenous retinal detachment Martin Cederlund1, Fredrik Ghosh2, Karin Arnér2, Sten Andréasson2, Bo Åkerström1 Divisions of 1Infection medicine and 2Ophthalmology, Department of Clinical Sciences, Lund University, Lund, Sweden. Corresponding author: Bo Åkerström, Division of Infection Medicine, Department of
Anslaget är öronmärkt till prekliniska studier i sen fas om njurskydd med läkemedelskandidaten ROSgard(tm) vid strålbehandling. Studierna bedrivs i samarbete mellan professor Åkerström och A1M Pharma. Bo Åkerström is a Professor of Medical Chemistry since 2000, currently Head of the Division of Infection Medicine at Lund University. Major focuses of research activity: 1) study properties, molecular mechanisms and therapeutic applications of the human antioxidation protein alpha-1-microglobulin (A1M), 2) study molecular mec hanisms, pathological mechanisms, and physiological defense Söndagsintervjun: Bo Åkerström & Martin Austin, A1M Pharma 18 december, 2016 Tidigare under hösten meddelade A1M Pharma att man valt njurskydd i samband med målsökande strålbehandling av tumörer, s.k. PRRT-behandling, som första inriktning … Bo Åkerström, Division of Infection Medicine, Department of Clinical Sciences in Lund, Lund University, BMC B14, 221 84 Lund, Sweden.
Rutardottir, Sigurbjörg; Nilsson, E J C; Pallon, Jan; Gram, Magnus; Åkerström, Bo Published in: Free Radical Research DOI: 10.3109/10715762.2013.801555 2013 Link to publication Citation for published
Bo Åkerström har ägnat hela sitt yrkesliv åt att förstå och beskriva proteinet A1M och de senaste tio åren har vi studerat det i laboratoriet som möjligt läkemedel. De kliniska studierna blir avgörande. Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its physiological role remained unknown for a long time. A series of recent publications have demonstrated that A1M is a vital part of tissue hou …
Early reports proposed an immunoregulatory role of A1M (Babiker-Mohamed et al., 1990a; Åkerström et al., 2000), but more recent reports have presented data of enzymatic reductase activity as well as heme- and radical binding functions, which reconceptualized the biological role to a housekeeping protein responsible for cleaning of tissues and antioxidant protection (Åkerström and Gram, 2014). Bo Åkerström is a Professor of Medical Chemistry since 2000, currently Head of the Division of Infection Medicine at Lund University.
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The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions Amanda Kristiansson , Magnus Gram , Johan Flygare , Stefan R Hansson , Bo Åkerström & Jill R Storry , 2020 Sep 30 , In : International Journal of Molecular Sciences. 21 , 19 , p. 1-21 7234.
(tgA1M) and tagless A1M (ntA1M) in a rather similar fashion although the His-tag is very likely involved into coordination with iron of the heme molecule. α1-microglobulin (A1M) is a small protein present in vertebrates including humans. It has several physiologically relevant properties, including binding of heme and radicals as well as enzymatic reduction, that are used in the protection of cells and tissue.
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Early reports proposed an immunoregulatory role of A1M (Babiker-Mohamed et al., 1990a; Åkerström et al., 2000), but more recent reports have presented data of enzymatic reductase activity as well as heme- and radical binding functions, which reconceptualized the biological role to a housekeeping protein responsible for cleaning of tissues and antioxidant protection (Åkerström and Gram, 2014).
A series of recent publications have demonstrated that A1M is a vital part of tissue hou … The authors Magnus Gram and Bo Åkerström are founders and share-holders of A1M Pharma. This does not alter the authors’ adherence to the policies of IJMS regarding sharing data and materials. References Early reports proposed an immunoregulatory role of A1M (Babiker-Mohamed et al., 1990a; Åkerström et al., 2000), but more recent reports have presented data of enzymatic reductase activity as well as heme- and radical binding functions, which reconceptualized the biological role to a housekeeping protein responsible for cleaning of tissues and antioxidant protection (Åkerström and Gram, 2014). 2021-02-10 Bo Åkerström. Söndagsintervjun: Bo Åkerström & Martin Austin, A1M Pharma.